E2F1-MEDIATED INDUCTION OF NFYB ATTENUATES APOPTOSIS VIA JOINT REGULATION OF A PRO-SURVIVAL TRANSCRIPTIONAL PROGRAM.

E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.

The E2F1 transcription factor regulates cell proliferation and apoptosis through the control of a considerable variety of target genes.Previous work has detailed the Valves role of other transcription factors in mediating the specificity of E2F function.Here we identify the NF-YB transcription factor as a novel direct E2F1 target.Genome-wide expres

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Leveraging Concept-Enhanced Pre-Training Model and Masked-Entity Language Model for Named Entity Disambiguation

Named Entity Disambiguation (NED) refers to the task of resolving multiple named entity mentions in an input-text sequence to their correct references in a knowledge graph.We tackle NED problem Joggers by leveraging two novel objectives for pre-training framework, and propose a novel pre-training NED model.Especially, the proposed pre-training NED

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A Label Free Colorimetric Assay for the Detection of Active Botulinum Neurotoxin Type A by SNAP-25 Conjugated Colloidal Gold

Botulinum neurotoxins are one of the most potent toxins known to man.Current methods of detection involve the quantification of the toxin but do not take into account the percentage of the toxin that is active.At present the assay used for monitoring the activity of the toxin is the mouse bioassay, which is lengthy and has ethical issues Styling SP

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